Global Medical Grade Nitric Oxide Market Report

Global Medical Grade Nitric Oxide Market Size, Share, Trends & Growth Analysis Report Segmented By Type (Inhaled Nitric Oxide, Nitric Oxide Gas, Nitric Oxide Delivery Systems), Application, End User And Regions (North America, Europe, Asia-Pacific, Latin America, Middle East and Africa), 2025-2033
Global Medical Grade Nitric Oxide Market is poised for a significant growth, with market size projected to surge from USD 1.68 Billion in 2024 to USD 3.82 Billion by 2033, showcasing a robust Compound Annual Growth Rate (CAGR) of 9.58% during the forecast period.
Medical Grade Nitric Oxide Market Size and Forecast 2025 to 2033
The global medical grade nitric oxide market is experiencing significant expansion, primarily fueled by its established efficacy in treating various respiratory and cardiovascular conditions. A key market driver is the rising incidence of pulmonary hypertension, especially in neonates, where inhaled nitric oxide is a critical therapy for improving oxygenation and reducing the need for extracorporeal membrane oxygenation (ECMO). The increasing prevalence of chronic obstructive pulmonary disease (COPD) and other severe respiratory disorders also contributes to demand, as nitric oxide therapy is being explored for its vasodilatory effects. The Centers for Disease Control and Prevention (CDC) consistently report on the burden of respiratory diseases, underscoring the ongoing need for advanced therapeutic options.
Opportunities in the market are abundant, particularly with the ongoing research into new therapeutic applications for medical grade nitric oxide beyond its current approved indications. This includes its potential use in treating acute respiratory distress syndrome (ARDS) in adults and other critical care scenarios. The advancements in nitric oxide delivery systems, making therapy more portable and accessible, also present a significant growth avenue. Furthermore, the increasing awareness among healthcare professionals about the benefits of nitric oxide therapy, coupled with supportive regulatory frameworks for orphan drugs and innovative treatments, is fostering market penetration and creating new avenues for expansion.
Market Dynamics
Medical Grade Nitric Oxide Market Drivers
- Increasing Incidence of Pulmonary Hypertension, Especially in Neonates: The rising global incidence of pulmonary hypertension, particularly in persistent pulmonary hypertension of the newborn (PPHN), is a primary driver for the medical grade nitric oxide market. Inhaled nitric oxide (iNO) is an approved and crucial therapy for PPHN, improving oxygenation and reducing the need for more invasive treatments like ECMO. The Centers for Disease Control and Prevention (CDC) consistently reports on neonatal health outcomes, highlighting the ongoing prevalence of respiratory challenges in newborns. This demographic necessity, coupled with the established clinical benefits of iNO in these delicate patients, ensures a sustained and growing demand for medical grade nitric oxide as a life-saving intervention in neonatal intensive care units globally.
- Growing Burden of Respiratory Disorders in Adults: The escalating global burden of severe respiratory disorders in adults, such as acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD) exacerbations, is significantly driving the medical grade nitric oxide market. While not always a first-line treatment, nitric oxide is increasingly explored for its vasodilatory and anti-inflammatory properties in these critical conditions. The World Health Organization (WHO) continuously reports on the high mortality and morbidity associated with respiratory diseases worldwide, emphasizing the urgent need for effective therapeutic interventions. As healthcare systems grapple with these widespread conditions, the utility of medical grade nitric oxide as an adjunctive therapy to improve oxygenation and reduce pulmonary vascular resistance contributes to its expanding market.
- Advancements in Nitric Oxide Delivery Systems: Continuous advancements in nitric oxide delivery systems are a crucial driver for market growth, enhancing the accessibility, efficiency, and safety of iNO therapy. Innovations in compact, user-friendly devices allow for more precise dosing, continuous monitoring, and even potential for home care applications. The U.S. Food and Drug Administration (FDA) has approved various advanced medical devices that integrate seamlessly with ventilation systems, improving therapeutic outcomes. These technological improvements simplify the administration of medical grade nitric oxide, reduce the complexity of patient management, and expand its potential use beyond specialized intensive care units, thereby broadening its adoption across a wider range of healthcare settings.
- Rising Awareness and Clinical Acceptance of Nitric Oxide Therapy: The increasing awareness among healthcare professionals and the growing clinical acceptance of medical grade nitric oxide therapy for its established and emerging applications are significantly driving the market. Extensive clinical research, often supported by institutions like the National Institutes of Health (NIH), has consistently demonstrated the therapeutic benefits of iNO in conditions like PPHN and its potential in other vasodilatory applications. This growing body of evidence, coupled with widespread dissemination of clinical guidelines and educational initiatives, encourages greater adoption by clinicians. As more medical professionals become familiar with its appropriate use and favorable outcomes, the therapeutic integration of medical grade nitric oxide expands, fueling market demand.
Medical Grade Nitric Oxide Market Opportunities
- Expansion into New Therapeutic Indications: The ongoing research and development into new therapeutic indications beyond established uses present a significant opportunity for the medical grade nitric oxide market. This includes exploring its potential in treating various cardiovascular conditions, infectious diseases, and even certain types of cancer. For instance, the National Institutes of Health (NIH) consistently funds research into the pleiotropic effects of nitric oxide in various physiological and pathological processes. As clinical trials progress and new applications gain regulatory approval, the market for medical grade nitric oxide could expand significantly, addressing unmet medical needs and offering novel treatment modalities, thereby unlocking substantial growth potential in diverse therapeutic areas.
- Development of Portable and Ambulatory Nitric Oxide Delivery Systems: The development of portable and ambulatory nitric oxide delivery systems represents a substantial market opportunity, facilitating wider patient access and improving quality of life. Current therapy primarily occurs in hospital settings, but technological advancements could enable its use in home care or during patient transport. The U.S. Department of Health and Human Services emphasizes patient-centric care and access to treatments outside traditional hospital walls. Miniaturized and user-friendly devices would allow patients with chronic conditions requiring nitric oxide to receive therapy more conveniently, reducing healthcare costs associated with extended hospital stays and significantly expanding the market reach beyond critical care units into a broader outpatient setting.
- Increased Investment in Research and Development by Pharmaceutical Companies: The growing investment by pharmaceutical companies in research and development related to nitric oxide and its derivatives presents a considerable market opportunity. This investment is aimed at developing novel nitric oxide-releasing compounds or more efficient delivery mechanisms for various therapeutic applications. The U.S. Food and Drug Administration (FDA) provides frameworks for expediting the development of innovative drugs, including those for rare diseases. Pharmaceutical companies are exploring new formulations, such as inhaled aerosols or systemic delivery methods, to broaden the therapeutic window and improve patient outcomes. This R&D focus is expected to lead to the introduction of new products and expand the overall scope and value of the medical grade nitric oxide market.
- Growing Healthcare Infrastructure and Expenditure in Emerging Economies: The continuous growth in healthcare infrastructure and increasing healthcare expenditure in emerging economies offer a significant opportunity for the medical grade nitric oxide market. As these regions develop, there is a rising demand for advanced medical therapies and critical care facilities. For example, the World Health Organization (WHO) often highlights the increasing healthcare investments in developing nations. Improved access to modern hospitals, trained medical professionals, and advanced medical equipment in countries across Asia Pacific and Latin America will drive the adoption of medical grade nitric oxide for conditions like PPHN and acute respiratory distress. This expansion of healthcare capacity creates new patient populations and untapped markets for nitric oxide therapy.
Medical Grade Nitric Oxide Market Restrain & Challenges
- High Cost of Nitric Oxide Therapy and Delivery Systems: The medical grade nitric oxide market faces a significant restraint due to the high cost associated with both the nitric oxide gas itself and its specialized delivery systems. The manufacturing process of medical-grade gas, coupled with the sophisticated equipment required for precise and safe administration, contributes to a substantial financial burden on healthcare systems and patients. The U.S. Centers for Medicare & Medicaid Services often evaluates the cost-effectiveness of various medical treatments. This high cost can limit the widespread adoption of nitric oxide therapy, particularly in developing regions or in healthcare settings with budget constraints, thereby impacting market penetration and accessibility despite its proven clinical benefits.
- Complex Regulatory Approval Process: The medical grade nitric oxide market is challenged by a complex and lengthy regulatory approval process. As a pharmaceutical gas, it undergoes rigorous scrutiny from regulatory bodies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) to ensure safety, efficacy, and consistent quality. This involves extensive clinical trials, documentation, and compliance with Good Manufacturing Practices (GMP). The arduous nature of these approvals, often taking several years and significant investment, can deter new market entrants and slow down the introduction of innovative delivery systems or new therapeutic indications, thereby acting as a notable restraint on market growth and innovation.
- Limited Approved Indications and Off-Label Use Concerns: A significant restraint for the medical grade nitric oxide market is its currently limited number of approved indications, primarily for persistent pulmonary hypertension of the newborn (PPHN). While there is ongoing research into other applications, off-label use for adult respiratory distress syndrome (ARDS) or other conditions, though sometimes practiced, carries regulatory and reimbursement challenges. The U.S. Department of Health and Human Services provides guidelines on appropriate drug usage. This restricted scope of approved applications limits the overall market size and potential revenue streams for manufacturers. The lack of broader official approvals can also lead to hesitation among clinicians due to liability concerns, thus impeding wider adoption.
- Risk of Methemoglobinemia and Other Adverse Effects: The administration of medical grade nitric oxide carries inherent risks, notably the potential for methemoglobinemia, a condition where oxygen delivery to tissues is impaired. While manageable with careful monitoring, this adverse effect necessitates vigilant patient observation and specialized equipment, adding complexity to its use. The U.S. National Institutes of Health (NIH) emphasizes the importance of understanding drug side effects and monitoring. Other potential adverse effects include rebound pulmonary hypertension upon abrupt discontinuation. These safety concerns require stringent protocols, trained personnel, and continuous monitoring, which can be challenging to implement in all healthcare settings. The risks associated with its use act as a restraint, requiring careful clinical judgment and limiting its application to controlled environments.
Current Trends in the Medical Grade Nitric Oxide Market
- Focus on Personalized Dosing and Monitoring: A significant trend in the medical grade nitric oxide market is the increasing focus on personalized dosing and advanced patient monitoring. This trend is driven by the desire to optimize therapeutic outcomes and minimize adverse effects by tailoring nitric oxide delivery to individual patient needs. The U.S. National Institutes of Health (NIH) consistently funds research into personalized medicine approaches. Innovations in delivery systems now incorporate real-time monitoring of physiological parameters, allowing clinicians to adjust nitric oxide concentrations precisely. This personalized approach aims to achieve optimal vasodilation and oxygenation while avoiding potential complications like methemoglobinemia, leading to more efficient and safer therapy, and enhancing the overall efficacy of treatment.
- Development of Next-Generation Nitric Oxide Generators: The market is witnessing a trend towards the development of next-generation nitric oxide generators, moving beyond traditional gas cylinders. These innovative systems aim to produce nitric oxide on-demand from ambient air or other precursors, offering advantages such as reduced logistical burden, improved portability, and potentially lower costs. The U.S. Food and Drug Administration (FDA) supports the development of novel medical devices that enhance patient care. Such advancements address the challenges associated with storing and transporting large gas cylinders and provide greater flexibility in administering nitric oxide therapy, potentially broadening its use in non-traditional settings and improving accessibility in remote or resource-constrained areas.
- Exploration of Nitric Oxide in Combination Therapies: A notable trend in the medical grade nitric oxide market is the increasing exploration of its use in combination therapies. Researchers are investigating how nitric oxide can synergistically interact with other drugs or medical interventions to improve patient outcomes in various conditions. The National Institutes of Health (NIH) often highlights promising results from combination therapy trials. For instance, studies are examining its combination with other vasodilators, anti-inflammatory agents, or even mechanical ventilation strategies to enhance therapeutic efficacy in complex respiratory and cardiovascular diseases. This approach aims to leverage the unique properties of nitric oxide to create more comprehensive and effective treatment regimens, opening new avenues for clinical application and market growth.
- Adoption of Digital Health and Telemedicine for Therapy Management: The increasing adoption of digital health platforms and telemedicine solutions is emerging as a trend in the medical grade nitric oxide market, particularly for long-term or home-based therapy management. These technologies enable remote monitoring of patients receiving nitric oxide, facilitate communication between healthcare providers and caregivers, and assist in managing equipment. The U.S. Department of Health and Human Services has been actively promoting telemedicine for improved patient access and care coordination. While still nascent for acute nitric oxide delivery, digital health solutions can support outpatient follow-up, track adherence, and provide alerts for potential issues, potentially extending the reach and efficiency of nitric oxide therapy beyond the confines of the hospital.
Segmentation Insights
Medical Grade Nitric Oxide Market Analysis, By Type
By Type, the market is categorized into Inhaled Nitric Oxide, Nitric Oxide Gas, Nitric Oxide Delivery Systems.
- Among the types of medical grade nitric oxide, Nitric Oxide Delivery Systems hold the largest market share. This leading position is primarily due to the critical and indispensable role these systems play in the safe and effective administration of medical grade nitric oxide gas. The delivery systems are complex medical devices designed to precisely control the flow and concentration of nitric oxide, ensuring optimal therapeutic benefit while minimizing the risk of adverse effects. Without these specialized systems, the therapeutic application of nitric oxide would be impossible. Continuous technological advancements in these devices, focusing on user-friendliness, portability, and integration with existing hospital infrastructure, further cement their dominant position as an essential component of nitric oxide therapy.
- The Inhaled Nitric Oxide segment is experiencing the fastest growth within the medical grade nitric oxide market. This rapid expansion is primarily driven by the increasing awareness and widespread clinical adoption of inhaled nitric oxide therapy, particularly for conditions like persistent pulmonary hypertension of the newborn (PPHN). Inhaled nitric oxide directly targets the pulmonary vasculature, leading to selective vasodilation and improved oxygenation with minimal systemic effects. The growing body of clinical evidence supporting its efficacy and safety in critical care settings, coupled with expanding patient populations requiring respiratory support, is fueling this accelerated growth. Furthermore, ongoing research into new applications for inhaled nitric oxide in adult respiratory conditions is contributing significantly to its rapid market expansion.
Medical Grade Nitric Oxide market Analysis, By Application
By Application Type, the market is categorized into Respiratory Disorders, Cardiovascular Diseases, Pulmonary Hypertension, Neonatal Care, and Other Medical Applications.
- The Neonatal Care application segment holds the largest share in the medical grade nitric oxide market. This dominance is primarily driven by the established and critical role of inhaled nitric oxide (iNO) in treating persistent pulmonary hypertension of the newborn (PPHN). iNO is a standard of care for these fragile patients, significantly improving oxygenation and reducing the need for more invasive interventions such as extracorporeal membrane oxygenation (ECMO). The high incidence of respiratory complications in premature and critically ill neonates, coupled with the proven efficacy and relatively safe profile of iNO in this vulnerable population, ensures a consistent and high demand from neonatal intensive care units globally.
- The Respiratory Disorders application segment is experiencing the fastest growth within the medical grade nitric oxide market. This rapid expansion is fueled by the escalating global burden of severe respiratory conditions in both adult and pediatric populations, beyond just neonatal care. While PPHN remains a core application, there is increasing research and off-label use of nitric oxide for conditions like acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD) exacerbations, and other severe lung injuries. The World Health Organization (WHO) continuously highlights the rising prevalence of respiratory diseases. As medical professionals explore the vasodilatory and anti-inflammatory properties of nitric oxide for a broader range of respiratory challenges, this segment is witnessing accelerated adoption and clinical investigation.
Medical Grade Nitric Oxide market Analysis, By End User
By End User Type, the market is categorized into Hospitals, Home Care Settings, Research Laboratories, Ambulatory Surgical Centers, and Other End Users.
- The Hospitals end-user segment holds the largest share in the medical grade nitric oxide market. This dominance is fundamentally driven by the fact that the primary application of medical grade nitric oxide, particularly inhaled nitric oxide for conditions like persistent pulmonary hypertension of the newborn (PPHN) and acute respiratory distress syndrome (ARDS), requires intensive care unit (ICU) settings. Hospitals are equipped with the specialized medical infrastructure, trained personnel, and sophisticated nitric oxide delivery systems necessary for the safe and effective administration and monitoring of this therapy. The critical nature of the conditions treated with nitric oxide necessitates a hospital environment for immediate medical intervention and continuous patient supervision.
- The Home Care Settings end-user segment is experiencing the fastest growth within the medical grade nitric oxide market, albeit from a smaller base. This rapid expansion is primarily driven by the increasing focus on reducing healthcare costs, improving patient convenience, and the development of more portable and user-friendly nitric oxide delivery systems. While currently limited to specific chronic conditions or post-hospitalization care, the trend towards shifting appropriate therapies to home environments is gaining momentum. The U.S. Department of Health and Human Services supports initiatives for expanding home-based care. As technological advancements make nitric oxide administration safer and simpler outside of traditional hospital walls, this segment is poised for significant growth, catering to patients requiring long-term or intermittent therapy.
Medical Grade Nitric Oxide Market Regional Insights
The market has been geographically analysed across five regions, Europe, North America, Asia Pacific, Latin America, and the Middle East & Africa.
- North America is the largest region in the medical grade nitric oxide market. This dominance is primarily attributable to several factors, including highly developed healthcare infrastructure, significant healthcare expenditure, and a high incidence of conditions such as persistent pulmonary hypertension of the newborn (PPHN) and other respiratory disorders where nitric oxide therapy is well-established. The presence of key market players, robust research and development activities, and supportive regulatory frameworks for novel therapies also contribute to its leading position. The U.S. Centers for Disease Control and Prevention (CDC) consistently reports on various health conditions, highlighting the ongoing need for advanced medical treatments and the region's strong adoption of approved therapeutic gases.
- Asia Pacific is the fastest-growing region in the medical grade nitric oxide market. This rapid expansion is primarily fueled by the improving healthcare infrastructure, increasing healthcare expenditure, and a rising awareness regarding advanced medical therapies across countries like China, India, and other emerging economies. The region is experiencing a significant increase in birth rates, which contributes to a higher incidence of neonatal respiratory complications requiring nitric oxide therapy. The World Health Organization (WHO) often highlights the expanding healthcare investments in these developing nations. Furthermore, the growing number of hospitals equipped with intensive care units and the increasing focus on modernizing healthcare facilities are collectively driving the accelerated demand for medical grade nitric oxide in the Asia Pacific region.
Medical Grade Nitric Oxide Market Competitive Overview
The global medical grade nitric oxide market is characterized by a moderately consolidated competitive landscape, with a few major players dominating a significant share. Competition revolves around product quality, regulatory approvals for new indications, the efficacy of delivery systems, and pricing strategies. Companies are heavily investing in research and development to enhance existing products, develop novel delivery methods, and explore new therapeutic applications for nitric oxide. Strategic alliances, partnerships with healthcare providers, and geographical expansion are common tactics employed by market participants to strengthen their market presence. Adherence to stringent regulatory standards and the ability to ensure a consistent and reliable supply of medical-grade gas are crucial competitive differentiators in this specialized market.
Leading Market Players in the Medical Grade Nitric Oxide Market
- Mallinckrodt Pharmaceuticals: Mallinckrodt Pharmaceuticals is a prominent player in the medical grade nitric oxide market, primarily known for its inhaled nitric oxide product, which is widely used for treating persistent pulmonary hypertension of the newborn (PPHN). The company has a strong focus on specialty pharmaceuticals and medical devices that address critical care needs. Mallinckrodt's commitment to patient safety and product quality is evident in their rigorous manufacturing processes and comprehensive support services for healthcare providers. Their established presence in hospitals and intensive care units globally, combined with ongoing efforts to educate clinicians on the appropriate use of nitric oxide therapy, solidifies their leading position in this therapeutic area.
- Praxair Technologies (now part of Linde plc): Praxair Technologies, now integrated into Linde plc, is a significant supplier of medical gases, including medical grade nitric oxide. The company leverages its extensive global infrastructure and expertise in gas production and distribution to serve healthcare facilities worldwide. Praxair Technologies focuses on ensuring a reliable and consistent supply of high-purity medical grade nitric oxide, alongside the development and maintenance of advanced delivery systems. Their strong relationships with hospitals and healthcare networks, coupled with their comprehensive portfolio of medical gas solutions, contribute to their robust market presence as a key provider of essential therapeutic gases for critical care applications.
- Linde plc: Linde plc is a global industrial gases and engineering company with a substantial footprint in the medical grade nitric oxide market, following its merger with Praxair. The company offers a complete range of medical gases, including medical grade nitric oxide, along with associated equipment and services for healthcare providers. Linde's strength lies in its vast production capabilities, sophisticated logistics, and commitment to innovation in gas delivery and patient care solutions. They focus on providing safe, reliable, and high-quality medical gases to hospitals, clinics, and other healthcare settings globally, supporting critical respiratory and cardiovascular therapies. Their expansive network and deep industry expertise position them as a dominant force in the medical gas sector.
Top Strategies Followed by Players
- Strategic Acquisitions and Collaborations to Expand Product Portfolios: A prominent strategy adopted by players in the medical grade nitric oxide market is engaging in strategic acquisitions and collaborations to expand their product portfolios and technological capabilities. For instance, the merger of Linde plc and Praxair Technologies exemplifies this trend, creating a global powerhouse in industrial and medical gases. These strategic moves allow companies to integrate complementary technologies, gain access to new markets, and broaden their offerings of medical grade nitric oxide alongside sophisticated delivery systems. Such collaborations also foster innovation by combining research and development efforts, leading to the introduction of more advanced and efficient therapeutic solutions for critical care applications.
- Investment in Research and Development for New Therapeutic Applications: Leading companies are heavily investing in research and development (R&D) to explore new therapeutic applications for medical grade nitric oxide beyond its currently approved indications. This strategy aims to unlock new market opportunities and address unmet medical needs. For example, the National Institutes of Health (NIH) consistently funds research into the vast physiological roles of nitric oxide, spurring interest in its potential. Companies are conducting clinical trials to investigate its efficacy in treating conditions like acute respiratory distress syndrome (ARDS) in adults, various cardiovascular diseases, and even certain infectious diseases. This R&D-driven approach is crucial for product diversification and for driving future market growth by expanding the clinical utility of nitric oxide therapy.
- Enhancing Delivery System Technology and Patient Monitoring: Another key strategy for players in the medical grade nitric oxide market is the continuous enhancement of delivery system technology and integrated patient monitoring solutions. This focus aims to improve the precision, safety, and user-friendliness of nitric oxide administration. For instance, the U.S. Food and Drug Administration (FDA) regularly reviews and approves new medical device technologies that enhance drug delivery. Companies are developing more compact, portable, and intelligent delivery systems that offer precise control over nitric oxide concentration, integrated real-time monitoring of physiological parameters, and alarm systems for adverse events. These technological advancements not only optimize therapeutic outcomes but also potentially enable the use of nitric oxide in a broader range of clinical settings, including outside of traditional intensive care units.
List of Companies Profiled in the Report are:
- Mallinckrodt Pharmaceuticals
- Praxair Technologies
- Linde plc
- Air Products and Chemicals Inc.
- Boehringer Ingelheim
- Global Nitric Oxide LLC
- NantWorks LLC
- Merck KGaA
- Noxopharm Limited
- Respiratory Technologies Inc.
- Fujifilm Corporation.
Global Medical Grade Nitric Oxide Market Report: Scope
Report Details | Attributes |
Base Year | 2024 |
Estimated Year | 2025 |
Historic Year | 2021-2023 |
Forecast Period | 2025-2033 |
Market Value | USD Billion & Volume in Tons |
Key Segments |
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Regional Coverage |
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Companies Profiled |
*No Particular order has been followed while listing the company names. |
List of Segments Covered
This section of the Medical Grade Nitric Oxide market report provides detailed data on the segments at country and regional level, thereby assisting the strategist in identifying the target demographics for the respective product or services with the upcoming opportunities.
By Type
- Inhaled Nitric Oxide
- Nitric Oxide Gas
- Nitric Oxide Delivery Systems
By Application
- Respiratory Disorders
- Cardiovascular Diseases
- Pulmonary Hypertension
- Neonatal Care
- Other Medical Applications
By End User
- Hospitals
- Home Care Settings
- Research Laboratories
- Ambulatory Surgical Centers
- Other End Users
Frequently Asked Questions (FAQs) about this Report
- Market Size and Forecast
- Market Dynamics
- Segmentation Insights
- Regional Insights
- Competitive Overview
- Recent Developments
- Scope of the Report
- List of Segments Covered
- FAQs
Insights You Can Expect From This Report

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