New Applications in Therapeutic Drugs to Push Mass Spectrometry Market Up

Posted On December 15, 2020     

The environment consists of thousands of exogenous compounds that are exposed to an individual mainly through diet. Although bodies can detoxify most of such substances, some of these molecules and co – exposures may impact the efficacy of drugs. If one consumes alcohol before taking any pain killer, the ethanol found in the drink may affect the active agent. Therefore, it is advised not to take antibiotics and pain relievers with alcohol.

Bisphenol (BPA), which is an essential component used in the production of plastic, is also found in human bodies. As per scientists, this toxin has been accumulated in humans but in deficient concentrations and is not considered critical to human health. It has been found that this toxin also interacts with anti-cancer therapeutics, which leads to reduced effectiveness of drugs and, in some cases, to drug resistance.

Geinstein is a phytoestrogen that is derived from soybeans. It works as an active agent in hormone drugs, which are used to treat the menopausal symptom. It can also affect other types of drugs but mainly those who are hormone-related chemotherapeutics working against breast cancer.

These thousands of molecules that are present inside a human body have the ability to interact with therapeutics, particularly in critical phases of life like adolescence or pregnancy. These interactions between exogenous substances and drugs may have positive or negative effects.

In answer to this problem, high–resolution mass spectrometry is an important tool. It enables medical personnel to measure a large number of molecules in parallel with each other. This way relationship between all the exposomes (measurable exposures) and active agents can be investigated and established systematically. Moreover, improved bioinformatics algorithms help in analysing generated data sets that are the result of the above-mentioned investigation.

Hitherto, researchers had been looking for ways to analyze effects that a certain molecule causes on a specific receptor. Research such as this may lead to discoveries that we would not have otherwise made by using rational hypothesis.

A better and advanced understanding of interactions between exposomes and drugs may enable physicians to provide drug prescriptions based on individual needs. This would increase the effectiveness of the drugs while also minimizing side effects. Patients in the future could be pre-screened to determine the exposomes in his or her body through individual mechanisms. Although this development may take time, this systematic approach may turn out to be groundbreaking for Mass Spectrometry Market and may also benefit the early stages of drug development.

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