Crohn's Disease Treatment Market: Research Studies Identifies Reasons for Reduced Relapses

Posted On May 06, 2022     

In past years or so, there has been a significant increase in inflammatory bowel illnesses, such as Crohn's disease, among young people in Canada. This can be explained by numerous environmental factors, including a sedentary lifestyle, inadequate nutrition, and antibiotic usage. Moreover, Crohn's disease affects roughly 2,000 children and adolescents in Quebec. The rising prevalence of inflammatory bowel illness is cause for concern because it increases the risk of colorectal cancer.
A team has presented a research wherein they collected data for the last decade. Researchers have focused on Crohn's disease relapse rate in children and the factors linked with relapse. Their study is a huge contribution to the Crohn's Disease Treatment Market the team has observed a decrease in the relapse rate of Crohn's disease in youngsters.
Between 2009 and 2019, 639 Crohn's disease patients under 18 were followed at CHU Sainte-Justine. Patients diagnosed between 2009 and 2014 suffered a return of their disease. The situation occurred even though they underwent therapy in 70.9 per cent of cases, compared to 49.1 per cent of patients diagnosed between 2015 and 2019.
This decline could be attributed to an increase in the use of biotherapies for treating inflammatory bowel disease. This class of medications targets specific proteins in the inflammatory cascade. It includes biologics, which are manufactured from living cells, and biosimilars, which are comparable but less expensive alternatives to biologics.

More importantly, biological therapy targeting inflammatory molecules can keep children in remission. In fact, researchers claim that 50% of patients newly diagnosed with this condition will obtain a biological treatment in the next three months of follow-up. Thus, ensuring control of the disease before they acquire severe symptoms.
In situations of relapse, the following factors were identified:

  1. Treatment that is insufficiently tailored to the severity of the condition, resulting in an inadequate reaction

  2. At diagnosis, the disease was a very serious—hormonal effect, including a greater chance of recurrence in females, particularly throughout puberty.

Other factors found in adults and documented in the literature may apply to some young people, including contracting a bacterium, such as Clostridium difficile, which can lead to 

  1. Illness relapse

  2. Smoking

  3. Poor stress management

  4. Discontinuing treatment when symptoms diminish.

The research aids in the individualization of medicines in order to maintain children in remission more efficiently and rapidly. 

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