Big Development in Tissue Engineering Market: Researchers Develop a New Mechanism for Muscle Regeneration after Physiological Damage
Posted On December 30, 2021
Muscle regeneration occurs through a series of complex processes. The steps primarily involve a series of actions while relying on the stem cells. Muscle regeneration has been a widely explored field of research in past decades. However, most research works restricted themselves upon the mechanisms relating to other cells, including muscle stem cells. Due to this, there is a need for a fresh, larger perspective to design novel muscle regeneration technologies.
A new study brought forth by a research team might be able to develop this thought. The researchers devised a novel mechanism for the regeneration of muscle after physiological damage occurs in patients. The treatment prescribes dependence on the rearrangement of nuclei. The protective mechanism is a significant contribution to the development of the Tissue Engineering Market. It may open a wide area of opportunity for the understanding of muscle repair within disease and physiology.
The researchers stated that as per their findings, an alternative mechanism for regeneration is possible, known as muscle cell-autonomous. The team used varied in vitro models relating to injury and exercise models within mice and humans. In this manner, they discovered that nuclei get attracted towards the damage site after injury, thereby accelerating the contractile units' healing.
After this, the team dissected the molecular mechanism for exploration and observation. A series of experiments involving muscle cells were done in the laboratory. The tests showed that the movement of nuclei towards the injury sites leads to the delivery of mRNA molecules locally. The same mRNA molecules are then translated into proteins on the injury site and are responsible for building blocks to make muscle repair.
All these findings collectively bring immense clarity to the concept of muscle biology, muscle dysfunction, and physiology. The present might even become a stepping stone for other research studies on similar grounds.
This study introduces more broad principles for cell biology, such as nuclear transport to injury sites, in addition to its relevance for muscle research. The movement that occurs during nuclei (the largest organelles within the cell) is one of the most remarkable aspects of these cells. However, the reason for such a movement has remained unknown till now. The team showed a functional relevance for this phenomenon upon adulthood at the time of cellular regeneration and repair.